Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC048
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-29 10:04
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment New patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 19 individuals with a value less than 0.57 were subsequently diagnosed with PD. That is, 45.24% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.57 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 23, 'TN': 17, 'TP': 19, 'FP': 13}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 27, 'TN': 26, 'TP': 15, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 10, 'TN': 8, 'TP': 32, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 5.584
timePerCircleCoV 0.117521
timePerCircleSlope -0.0347313
meanError 2.09675
tremorFreq 6.64062
tremorRelPower 21.7318
tremorGyroAmpMean 0.0170771
tremorGyroAmpSlope 0.00092634
tremorGyroAmpCoV 0.297677
tremorCoordAmpMean 0.0395401
tremorCoordAmpSlope -0.00202984
tremorCoordAmpCoV 0.241822
tremorAccAmpMean 0.0281303
tremorAccAmpSlope -0.00294473
tremorAccAmpCoV 0.291253
tremorPcRelVar 0.616512
tremorPcX 0.832367
tremorPcY 0.554225

Circle Segment 1

Duration 7.04 s, Accuracy Estimate 1.757 (lower is better)

Circle Segment 2

Duration 6.2 s, Accuracy Estimate 2.732 (lower is better)

Circle Segment 3

Duration 5.84 s, Accuracy Estimate 2.224 (lower is better)

Circle Segment 4

Duration 5.84 s, Accuracy Estimate 1.579 (lower is better)

Circle Segment 5

Duration 5.4 s, Accuracy Estimate 2.235 (lower is better)

Circle Segment 6

Duration 5.08 s, Accuracy Estimate 2.569 (lower is better)

Circle Segment 7

Duration 5.16 s, Accuracy Estimate 1.853 (lower is better)

Circle Segment 8

Duration 5.28 s, Accuracy Estimate 1.721 (lower is better)

Circle Segment 9

Duration 5.04 s, Accuracy Estimate 1.891 (lower is better)

Circle Segment 10

Duration 4.96 s, Accuracy Estimate 2.407 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 15.616
timePerSpiralCoV 0.166376
timePerSpiralSlope -0.0520368
meanError 2.08621
tremorFreq 7.12891
tremorRelPower 28.8558
tremorGyroAmpMean 0.0183425
tremorGyroAmpSlope 0.00263115
tremorGyroAmpCoV 0.338965
tremorCoordAmpMean 0.0500889
tremorCoordAmpSlope 0.00195397
tremorCoordAmpCoV 0.299787
tremorAccAmpMean 0.0354266
tremorAccAmpSlope 0.00316745
tremorAccAmpCoV 0.314324
tremorPcRelVar 0.65678
tremorPcX -0.860505
tremorPcY 0.509441

Spiral Segment 1

Duration 20.92 s, Accuracy Estimate 2.007 (lower is better)

Spiral Segment 2

Duration 18.24 s, Accuracy Estimate 2.073 (lower is better)

Spiral Segment 3

Duration 17.04 s, Accuracy Estimate 1.98 (lower is better)

Spiral Segment 4

Duration 15.64 s, Accuracy Estimate 1.594 (lower is better)

Spiral Segment 5

Duration 15.4 s, Accuracy Estimate 2.388 (lower is better)

Spiral Segment 6

Duration 15.32 s, Accuracy Estimate 2.017 (lower is better)

Spiral Segment 7

Duration 14.84 s, Accuracy Estimate 1.997 (lower is better)

Spiral Segment 8

Duration 13.0 s, Accuracy Estimate 2.231 (lower is better)

Spiral Segment 9

Duration 13.64 s, Accuracy Estimate 2.303 (lower is better)

Spiral Segment 10

Duration 12.12 s, Accuracy Estimate 2.271 (lower is better)

Elel

eDurationMean 0.682083
eDurationStd 0.168313
eDurationStdnorm 0.246762
eDurationMedian 0.635
eDurationQuartdelta 0.1275
eDurationQuartdeltanorm 0.200787
eDurationKurt 14.4589
eDurationTrenddiff -0.065
eDurationTrendratio 0.904412
eWidthMean 5.33975
eWidthStd 1.16234
eWidthStdnorm 0.217676
eWidthMedian 5.3235
eWidthQuartdelta 1.4625
eWidthQuartdeltanorm 0.274725
eWidthKurt 3.79469
eWidthTrenddiff -0.234
eWidthTrendratio 0.956522
eHeightMean 10.816
eHeightStd 2.13522
eHeightStdnorm 0.197413
eHeightMedian 10.9395
eHeightQuartdelta 2.1645
eHeightQuartdeltanorm 0.197861
eHeightKurt 4.09131
eHeightTrenddiff -1.4625
eHeightTrendratio 0.873737
eAspectMean 0.505781
eAspectStd 0.124669
eAspectStdnorm 0.246487
eAspectMedian 0.490506
eAspectQuartdelta 0.105839
eAspectQuartdeltanorm 0.215775
eAspectKurt 7.48296
eAspectTrenddiff 0.0102905
eAspectTrendratio 1.02143
eSlantMean -0.199588
eSlantStd 0.182424
eSlantStdnorm -0.914004
eSlantMedian -0.185198
eSlantQuartdelta 0.22494
eSlantQuartdeltanorm -1.21459
eSlantKurt 2.91676
eSlantTrenddiff 0.0911686
eRtopMean 0.689696
eRtopStd 0.144517
eRtopStdnorm 0.209537
eRtopMedian 0.723839
eRtopQuartdelta 0.165028
eRtopQuartdeltanorm 0.22799
eRtopKurt 3.57144
eRtopTrenddiff 0.0589307
eRbotMean 1.12714
eRbotStd 0.342625
eRbotStdnorm 0.303976
eRbotMedian 1.10728
eRbotQuartdelta 0.451638
eRbotQuartdeltanorm 0.407881
eRbotKurt 3.10773
eRbotTrenddiff -0.0379098
eRrightMean 0.825229
eRrightStd 0.104361
eRrightStdnorm 0.126464
eRrightMedian 0.852504
eRrightQuartdelta 0.138161
eRrightQuartdeltanorm 0.162065
eRrightKurt 3.37489
eRrightTrenddiff 0.0159586
eRleftMean 0.489196
eRleftStd 0.121008
eRleftStdnorm 0.24736
eRleftMedian 0.468272
eRleftQuartdelta 0.181183
eRleftQuartdeltanorm 0.386919
eRleftKurt 3.29836
eRleftTrenddiff -0.0136262
lDurationMean 0.794474
lDurationStd 0.130678
lDurationStdnorm 0.164484
lDurationMedian 0.8
lDurationQuartdelta 0.135
lDurationQuartdeltanorm 0.16875
lDurationKurt 3.79919
lDurationTrenddiff -0.03
lDurationTrendratio 0.96319
lWidthMean 6.46579
lWidthStd 2.46979
lWidthStdnorm 0.381979
lWidthMedian 6.201
lWidthQuartdelta 3.51
lWidthQuartdeltanorm 0.566038
lWidthKurt 2.18804
lWidthTrenddiff 3.042
lWidthTrendratio 1.59091
lHeightMean 23.7048
lHeightStd 3.5478
lHeightStdnorm 0.149666
lHeightMedian 24.102
lHeightQuartdelta 4.563
lHeightQuartdeltanorm 0.18932
lHeightKurt 3.32186
lHeightTrenddiff 2.925
lHeightTrendratio 1.13514
lAspectMean 0.272305
lAspectStd 0.0953514
lAspectStdnorm 0.350164
lAspectMedian 0.262453
lAspectQuartdelta 0.172391
lAspectQuartdeltanorm 0.656846
lAspectKurt 1.9208
lAspectTrenddiff 0.0757345
lAspectTrendratio 1.30848
lSlantMean -0.0304122
lSlantStd 0.149291
lSlantStdnorm -4.9089
lSlantMedian -0.010153
lSlantQuartdelta 0.181797
lSlantQuartdeltanorm -17.9058
lSlantKurt 3.10207
lSlantTrenddiff 0.109708
lRtopMean 0.822084
lRtopStd 0.142129
lRtopStdnorm 0.172889
lRtopMedian 0.852455
lRtopQuartdelta 0.188177
lRtopQuartdeltanorm 0.220748
lRtopKurt 3.68446
lRtopTrenddiff 0.0160207
lRbotMean 1.15806
lRbotStd 0.793199
lRbotStdnorm 0.684937
lRbotMedian 0.926984
lRbotQuartdelta 0.71495
lRbotQuartdeltanorm 0.771265
lRbotKurt 4.81446
lRbotTrenddiff -0.455814
lRrightMean 0.909971
lRrightStd 0.0992913
lRrightStdnorm 0.109115
lRrightMedian 0.94424
lRrightQuartdelta 0.075678
lRrightQuartdeltanorm 0.080147
lRrightKurt 11.6754
lRrightTrenddiff -0.00774624
lRleftMean 0.370075
lRleftStd 0.180747
lRleftStdnorm 0.488408
lRleftMedian 0.318466
lRleftQuartdelta 0.204608
lRleftQuartdeltanorm 0.642482
lRleftKurt 2.65508
lRleftTrenddiff -0.0560869

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.914977
sumTouchScores 27.4493
meanMovementTime 0.617586
numTouches 30
undershootPercentage 0
overshootPercentage 13.3333

FITTS Long Modified

meanTouchScore 0.879634
sumTouchScores 18.4723
meanMovementTime 0.9465
numTouches 21
undershootPercentage 4.7619
overshootPercentage 28.5714

ZigZag

numZigzags 5
timePerZigzagMean 13.6
timePerZigzagCoV 0.0862522
timePerZigzagSlope -0.0147059
meanError 2.71848
tremorFreq 7.22656
tremorRelPower 22.5264
tremorGyroAmpMean 0.0202062
tremorGyroAmpSlope -0.000885774
tremorGyroAmpCoV 0.270024
tremorCoordAmpMean 0.141576
tremorCoordAmpSlope 0.002108
tremorCoordAmpCoV 0.974744
tremorAccAmpMean 0.0484557
tremorAccAmpSlope -0.00155728
tremorAccAmpCoV 0.258923
tremorPcRelVar 0.879932
tremorPcX 0.182688
tremorPcY -0.983171

ZigZag Segment 1

Duration 15.28 s, Accuracy Estimate 2.286 (lower is better)

ZigZag Segment 2

Duration 13.0 s, Accuracy Estimate 2.578 (lower is better)

ZigZag Segment 3

Duration 12.52 s, Accuracy Estimate 2.782 (lower is better)

ZigZag Segment 4

Duration 12.84 s, Accuracy Estimate 2.688 (lower is better)

ZigZag Segment 5

Duration 14.36 s, Accuracy Estimate 3.259 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 14.4267
timePerZigzagCoV 0.195778
timePerZigzagSlope -0.0822287
zigzagHeightMean 86.1177
zigzagHeightCoV 0.035877
zigzagHeightSlope 0.0106364
meanError 0.0642885
tremorFreq 6.83594
tremorRelPower 24.8445
tremorGyroAmpMean 0.0252034
tremorGyroAmpSlope 0.00392998
tremorGyroAmpCoV 0.306134
tremorCoordAmpMean 0.117995
tremorCoordAmpSlope 0.00654144
tremorCoordAmpCoV 1.18305
tremorAccAmpMean 0.0496139
tremorAccAmpSlope 0.00370205
tremorAccAmpCoV 0.337044
tremorPcRelVar 0.79193
tremorPcX 0.031589
tremorPcY -0.999501

ZigZag Offset Segment 1

Duration 14.92 s, Accuracy Estimate 0.132 (lower is better)

ZigZag Offset Segment 2

Duration 17.8 s, Accuracy Estimate 0.063 (lower is better)

ZigZag Offset Segment 3

Duration 17.4 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 4

Duration 13.36 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 5

Duration 12.44 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 6

Duration 10.64 s, Accuracy Estimate 0.071 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.79}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.57}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.25408287220321024}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8840643598784539}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}